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recombinant murine ip-10 (cxcl10) (peprotech #250-16)  (PeproTech)


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    Structured Review

    PeproTech recombinant murine ip-10 (cxcl10) (peprotech #250-16)
    Recombinant Murine Ip 10 (Cxcl10) (Peprotech #250 16), supplied by PeproTech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/recombinant+murine+ip-10+(cxcl10)/cxcl10+chemokine/pm40525671-217-4-7
    Average 90 stars, based on 1 article reviews
    recombinant murine ip-10 (cxcl10) (peprotech #250-16) - by Bioz Stars, 2026-11
    90/100 stars

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    Related Articles

    other:

    Article Title: The glucose transporter 2 regulates CD8 + T cell function via environment sensing
    Article Snippet: Recombinant murine IP-10 (250-16) and recombinant murine IFNγ (315-05) were purchased from PeproTech.

    Article Title: Modulating nano-bio interface via drug-framework hybridization to activate chemoimmunotherapy against glioma postoperative recurrence
    Article Snippet: Recombinant murine IP-10 (CXCL10) was purchased from PeproTech (New Jersey, USA).

    Article Title: In Vivo Accumulation of Regulatory T Cells Using Eliglustat-Loaded Cryogels.
    Article Snippet: Regulatory T cells (Tregs) maintain immune homeostasis and their adoptive transfer is being widely explored to mitigate inflammatory and autoimmune conditions.. Here a biomaterial is developed to accumulate Tregs at a specific anatomic location to bypass the need for ex vivo Treg isolation and adoptive transfer.. It is first shown that eliglustat, an FDA-approved inhibitor of UDP-glucose ceramide glucosyltransferase, promotes Tregs from both naïve and activated CD4+ T cells in vitro.

    Recombinant:

    Article Title: Islet‐Resident Memory T Cells Orchestrate the Immunopathogenesis of Type 1 Diabetes through the FABP4‐CXCL10 Axis
    Article Snippet: Activated CD8 + T cells (1 × 10 5 cells/well) were then seeded on the porous permeable membrane in the Trans‐well Supports (Corning). .. To assess the alarming function of FABP4 +/+ T RM and FABP4 −/− T RM cells and the involvement of CXCL10, the conditioned medium of respective cells were added to the lower wells. and supplemented with recombinant murine CXCL10 (2 g mL −1 , PeproTech) or IgG as control. ..

    Article Title: Microglia secrete distinct sets of neurotoxins in a stimulus-dependent manner.
    Article Snippet: Microglia are the resident immune cells of the brain which regulate both the innate and adaptive neuroimmune responses in health and disease.. In response to specific endogenous and exogenous stimuli, microglia transition to one of their reactive states characterized by altered morphology and function, including their secretory profile.. A component of the microglial secretome is cytotoxic molecules capable of causing damage and death to nearby host cells, thus contributing to the pathogenesis of neurodegenerative disorders.

    Article Title: Extracellular mixed histones are neurotoxic and modulate select neuroimmune responses of glial cells
    Article Snippet: MH from calf thymus (H9250-100MG), LPS from Escherichia coli O55:B5, the TLR4 inhibitor ethyl-(6 R )-6-( N -(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate (TAK-242), 3-(4,5-dimethyl-3-thiazoyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), bisbenzimide (Hoechst 33258), N -(1-naphthyl)ethylenediamine dihydrochloride, sulfanilamide, dimethyl sulfoxide (DMSO), beta-nicotinamide adenine dinucleotide (β-NAD), triethanolamine, diaphorase from Clostridium kluyveri , L-glutamic acid monosodium salt, and N , N -dimethylformamide (DMF) were purchased from Sigma-Aldrich (Oakville, ON, Canada). .. Human and murine recombinant interferon (IFN)-γ, and enzyme-linked immunosorbent assay (ELISA) development kits for human TNF, and both human and murine CXCL10 were acquired from Peprotech (Embrun, ON, Canada). .. Fluorescein isothiocyanate (FITC) surface-labelled fluorescent polystyrene latex beads (one μm diameter) were purchased from Bangs Laboratories (Fishers, IN, USA).

    Article Title: Islet-Resident Memory T Cells Orchestrate the Immunopathogenesis of Type 1 Diabetes through the FABP4-CXCL10 Axis.
    Article Snippet: Activated CD8+ T cells (1 × 105 cells/well) were then seeded on the porous permeable membrane in the Trans-well Supports (Corning). .. To assess the alarming function of FABP4+/+ TRM and FABP4−/− TRM cells and the involvement of CXCL10, the conditioned medium of respective cells were added to the lower wells. and supplemented with recombinant murine CXCL10 (2 g mL−1, PeproTech) or IgG as control. ..

    Article Title: Discovery of Clinical Candidate ACT-777991, a Potent CXCR3 Antagonist for Antigen-Driven and Inflammatory Pathologies.
    Article Snippet: The CXCR3 chemokine receptor is a G proteincoupled receptor mainly expressed on immune cells from the lymphoid lineage, including activated T cells.. Binding of its inducible chemokine ligands CXCL9, CXCL10, and CXCL11 leads to downstream signaling events and the migration of activated T cells to sites of inflammation.. Herein, we report the third part of our CXCR3 antagonist program in the field of autoimmunity, culminating in the discovery of the clinical compound ACT777991 (8a).

    Control:

    Article Title: Islet‐Resident Memory T Cells Orchestrate the Immunopathogenesis of Type 1 Diabetes through the FABP4‐CXCL10 Axis
    Article Snippet: Activated CD8 + T cells (1 × 10 5 cells/well) were then seeded on the porous permeable membrane in the Trans‐well Supports (Corning). .. To assess the alarming function of FABP4 +/+ T RM and FABP4 −/− T RM cells and the involvement of CXCL10, the conditioned medium of respective cells were added to the lower wells. and supplemented with recombinant murine CXCL10 (2 g mL −1 , PeproTech) or IgG as control. ..

    Article Title: Islet-Resident Memory T Cells Orchestrate the Immunopathogenesis of Type 1 Diabetes through the FABP4-CXCL10 Axis.
    Article Snippet: Activated CD8+ T cells (1 × 105 cells/well) were then seeded on the porous permeable membrane in the Trans-well Supports (Corning). .. To assess the alarming function of FABP4+/+ TRM and FABP4−/− TRM cells and the involvement of CXCL10, the conditioned medium of respective cells were added to the lower wells. and supplemented with recombinant murine CXCL10 (2 g mL−1, PeproTech) or IgG as control. ..

    Enzyme-linked Immunosorbent Assay:

    Article Title: Microglia secrete distinct sets of neurotoxins in a stimulus-dependent manner.
    Article Snippet: Microglia are the resident immune cells of the brain which regulate both the innate and adaptive neuroimmune responses in health and disease.. In response to specific endogenous and exogenous stimuli, microglia transition to one of their reactive states characterized by altered morphology and function, including their secretory profile.. A component of the microglial secretome is cytotoxic molecules capable of causing damage and death to nearby host cells, thus contributing to the pathogenesis of neurodegenerative disorders.

    Article Title: Extracellular mixed histones are neurotoxic and modulate select neuroimmune responses of glial cells
    Article Snippet: MH from calf thymus (H9250-100MG), LPS from Escherichia coli O55:B5, the TLR4 inhibitor ethyl-(6 R )-6-( N -(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate (TAK-242), 3-(4,5-dimethyl-3-thiazoyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), bisbenzimide (Hoechst 33258), N -(1-naphthyl)ethylenediamine dihydrochloride, sulfanilamide, dimethyl sulfoxide (DMSO), beta-nicotinamide adenine dinucleotide (β-NAD), triethanolamine, diaphorase from Clostridium kluyveri , L-glutamic acid monosodium salt, and N , N -dimethylformamide (DMF) were purchased from Sigma-Aldrich (Oakville, ON, Canada). .. Human and murine recombinant interferon (IFN)-γ, and enzyme-linked immunosorbent assay (ELISA) development kits for human TNF, and both human and murine CXCL10 were acquired from Peprotech (Embrun, ON, Canada). .. Fluorescein isothiocyanate (FITC) surface-labelled fluorescent polystyrene latex beads (one μm diameter) were purchased from Bangs Laboratories (Fishers, IN, USA).



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    Image Search Results


    Serum IP-10 levels normalize with DAA treatment and correlate with viral kinetic decline. ( A ) Serum IP-10 protein levels upon treatment. Statistical analysis showed a significant change over time regardless of treatment outcome that differed between HCV mono-infected and HCV/HIV co-infected. This difference disappeared at the end of follow-up. ( B ) Serum IP-10 levels at baseline and during treatment mirrored changes in viral load. LLOD, lower limit of detection for viral load. ( A , B ) Stepwise linear structural equation model predicted estimates are shown for the HCV mono-infected and the HCV/HIV co-infected. Statistically significant differences over time are marked by an arrow and asterisk. One asterisk corresponds to p < 0.05, two asterisks p < 0.001.

    Journal: Pathogens

    Article Title: Short- and Long-Term Immunological Responses in Chronic HCV/HIV Co-Infected Compared to HCV Mono-Infected Patients after DAA Therapy

    doi: 10.3390/pathogens10111488

    Figure Lengend Snippet: Serum IP-10 levels normalize with DAA treatment and correlate with viral kinetic decline. ( A ) Serum IP-10 protein levels upon treatment. Statistical analysis showed a significant change over time regardless of treatment outcome that differed between HCV mono-infected and HCV/HIV co-infected. This difference disappeared at the end of follow-up. ( B ) Serum IP-10 levels at baseline and during treatment mirrored changes in viral load. LLOD, lower limit of detection for viral load. ( A , B ) Stepwise linear structural equation model predicted estimates are shown for the HCV mono-infected and the HCV/HIV co-infected. Statistically significant differences over time are marked by an arrow and asterisk. One asterisk corresponds to p < 0.05, two asterisks p < 0.001.

    Article Snippet: Commercially available ELISA kits (Boster Biological Technology, Pleasanton, CA, USA) were used for the quantitative detection of plasma levels of interferon gamma-induced protein 10 (IP-10) according to the manufacturer’s instructions.

    Techniques: Infection